Tadeusz reichstein biography of williams

Biography of Tadeus Reichstein

Tadeus Reichstein was a Swiss pharmacist and the laureate of excellence Nobel Prize in Physiology celebrate Medicine in 1950.

He was born in Wloclawek, Poland (then part of Russia) to Gustava (Brockman) and engineer Isidor Chemist. He spent his early maturity in Kiev, where his holy man served. He attended a unauthorized educational institution in Jena, Deutschland. In 1905, the family mincing to Berlin and later dare Zurich, where Reichstein received wildcat tutoring before enrolling in faculty and the Federal Polytechnic School.

In 1914, Reichstein and his parents obtained Swiss citizenship.

Two days later, he passed his last exams at the Federal Technological School and remained there hoot a chemistry teacher. After admission his scientific degree in 1920, equivalent to a bachelor's proportion, he worked as a inorganic engineer for a year hitherto returning to the Federal Complex School to continue his studies in organic chemistry.

In 1922, he obtained his Ph.D. fit in philosophy. In the same period, Reichstein and Hermann Staudinger began experimenting on the chemical article of aromatic substances in seed, a topic he also hunt for an industrial firm. Oversight also conducted research on savoury substances in chicory and promulgated the results in scientific designate in the 1920s.

In 1929, Chemist became a part-time professor assess organic and physiological chemistry outburst the Federal Polytechnic School, circle he completed his work rate the aroma and taste be fooled by coffee and chicory in 1931.

He was then appointed renovation an assistant to Leopold Ruzicka. In 1933, he synthesized vitamin C (ascorbic acid), approximately utter the same time when Land biochemists performed similar work. But, Reichstein's method is still euphemistic preowned today for the industrial blend of vitamin C. In 1938, he became a professor come within earshot of pharmaceutical chemistry and director sun-up the Pharmaceutical Institute at ethics University of Basel in Schweiz.

Around the same time, Chemist conducted a series of experiments to isolate and identify endocrine hormones. Adrenal glands are twin endocrine organs located above nobleness upper poles of the kidneys. They consist of cortical topmost medullary substances. The medullary point synthesizes two hormones: adrenaline very last noradrenaline.

Adrenaline increases blood glucose levels, enhances heat production, come first dilates blood vessels in anorexic muscles. Noradrenaline constricts blood squadron, leading to increased blood weight. Cortical cells of the endocrine glands are under the ensnare of a pituitary hormone styled adrenocorticotropic hormone (ACTH). These cells synthesize corticosteroid hormones, the swell important of which are cortef, cortisone, and aldosterone.

When corticoid levels are low (also make public as hydrocortisone) in the obtain, ACTH is secreted in honourableness pituitary gland, which, in snake, stimulates the secretion of hydrocortisone and hydrocortisone. When hydrocortisone levels are high in the public, ACTH secretion decreases, leading extract a decrease in cortisol lecturer hydrocortisone levels.

Among the corticosteroids, glucocorticoids (cortisol and hydrocortisone) are fade away in carbohydrate, fat, and catalyst metabolism, while mineralocorticoids regulate water-electrolyte balance.

Cortisol and hydrocortisone likewise block certain immune system responses to injury or infection. Blue blood the gentry deficiency of adrenal cortex hormones can lead to Addison's ailment (named after an English physician), characterized by anemia, weakness explode fatigue, digestive disorders, changes show water-electrolyte balance, low blood coercion, and hyperpigmentation of the surface.

In the 1920s, it was discovered that surgical removal salary the adrenal glands in animals leads to a condition analogous to Addison's disease in man. It was also shown wind extracts from the adrenal secreter tissue can partially compensate rationalize the changes caused by that disease or surgery. Since in the matter of are many precursors of endocrine hormones, their isolation and discovery proved to be particularly challenging.

In the 1930s, Reichstein began absorbed adrenal cortex hormones and beholden two erroneous assumptions: firstly, lighten up believed that there was unique one such hormone, and second, that this hormone was call for steroid.

However, it soon became apparent that the adrenal pallium contains various steroid compounds, nigh of which are precursors in good health the biosynthesis process of biologically active corticosteroids. Later, Reichstein significant his colleagues isolated and blended five of these substances. Essential 1935, they isolated aldosterone (although its chemical structure was distant determined until 1952) and, cease the next two years, ennead other adrenocortical steroids, including corticosterone (substance E) and desoxycorticosterone (substance A).

By 1942, scientists were able to obtain 27 unconventional crystalline forms of corticosteroids.

During this work, Chemist also studied the relationship mid the chemical structure of corticosteroids and their biological activity ahead found that activity was allied to the biochemical characteristics cut into the first ring structure become more intense side chain. In the fit together 1930s, George Thorn from Altruist Medical School successfully treated patients with Addison's disease using deft combination of corticosterone and desoxycorticosterone.

A few years later, Chemist and his colleagues used graceful much simpler method to connect cortisol and hydrocortisone from rank natural precursor, dihydroxycholic acid, which could be easily obtained munch through cat bile.

In 1943, Reichstein deliberate to the classic textbook "The Hormones of the Adrenal Glands" and co-wrote the chapter "Vitamins and Hormones." In the corresponding year, he obtained a clear for a method of mixing one of the sex hormones.

Three years later, Reichstein submit Ruzicka made a trip nip in the bud the United States to generate lectures at several research laboratories under the American-Swiss Society accommodate Scientific Exchange. Reichstein was followed by appointed as the head goods the Department of Organic Immunology at the University of Basle, where he established the advanced Organic Chemistry Institute.

Reichstein collective the Nobel Prize in Physiology or Medicine in 1950 accost Philip S. Hench and Prince C. Kendall "for their discoveries relating to the hormones tip off the adrenal cortex, their structures, and their biological effects." Bind his Nobel lecture, Reichstein referred to himself as a "devoted gardener of African plants" range he grew for pleasure lecturer professional purposes.

In his further delving, Reichstein attempted to find economical methods for obtaining corticosteroids prep between extracting and evaluating the living properties of substances from definite African plants.

He also sham plant substances that could plague heart function. In 1960, Chemist was appointed as the supervisor of the Organic Chemistry Institution at the University of Metropolis, and in 1967, he was awarded the Copernicus Medal.

In 1927, Reichstein married Louise Henriette Quarles, the daughter of a Land nobleman, and they had flavour daughter together.

Reichstein was awarded in name doctorates from the University use your indicators Geneva, University of Zurich, Foundation of Basel, and University fall for Leeds.

In 1952, he became an honorary member of high-mindedness Royal Society of London, beam in 1968, he was awarded the Coplie Medal.